Intraepithelial T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2
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چکیده
Intraepithelial T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2 Hitoshi Nishimura, Toshiki Yajima, Yoshiko Kagimoto, Mutsuhiro Ohata, Taketo Watase, Kenji Kishihara, Fumi Goshima, Yukihiro Nishiyama, and Yasunobu Yoshikai* Division of Host Defense, Medical Institute for Bioregulation, Kyushu University, Fukuoka 812-8582, and Laboratory of Host Defense and Germfree Life, and Laboratory of Virology, Research Institute for Disease Mechanism & Control, Nagoya University School of Medicine, Nagoya 466-8550, Japan
منابع مشابه
Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes.
Herpes simplex virus (HSV) infections of humans are characterized by intermittent, lytic replication in epithelia. Circulating HSV-specific CD4 T cells express lower levels of preformed cutaneous lymphocyte-associated antigen (CLA), a skin-homing receptor, than do circulating HSV-specific CD8 T cells but, paradoxically, move into infected skin earlier than CD8 cells. Memory CD4 T cells develop ...
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